For large or recurrent keloids

Surgical Stack

Research evidence: Strong5 steps12-24 months including all adjuncts and follow-up

Last reviewed: April 2026

Surgical excision is high-recurrence when used alone — up to 100% in some series. This protocol pairs excision with post-op radiation and long-term silicone to bring recurrence down to roughly 10-30% in the literature.

Who this is for

  • Large, bulky, or pedunculated keloids unlikely to respond to injection
  • Recurrent keloids that have failed prior steroid or 5-FU therapy
  • High-tension sites (chest, shoulder) where volume reduction is essential
  • Patients committed to the full multi-month adjunct protocol

Not ideal for

  • Pediatric patients (radiation is generally avoided in children)
  • Patients unable to access both a surgeon and a radiation oncologist
  • Small keloids where steroid-based stacks have not yet been tried

The protocol, step by step

  1. Surgery

    Day 0 — outpatient procedure, tension-free closure

    Physical volume reduction. Must be paired with adjunct therapy — excision alone has the worst recurrence rates in the literature.

  2. Radiation Therapy

    Within 24-72 hours of surgery — typically 12-20 Gy in 3-5 fractions, or brachytherapy

    Damage rapidly dividing fibroblasts in the healing wound to interrupt the keloid regrowth cascade.

  3. Silicone Sheets

    Starting as soon as the wound is fully closed, daily for 3-6 months

    Support remodeling of the new scar and reduce the inflammatory drive that can restart keloid formation.

  4. Steroid Injections

    Optional — at 3-4 weeks post-op if early regrowth appears, then every 4-8 weeks as needed

    Backup biologic suppression if scar margins show signs of reactivation during healing.

  5. Red Light Therapy

    10-20 minute sessions, 3-7 times per week, starting 2-4 weeks after the radiation course is complete and skin has settled

    Support long-term remodeling and modulate fibroblast signaling once the wound and irradiated skin have healed. Treat as an emerging adjunct, not a replacement for radiation or silicone.

    Devices reviewed

    If you want to explore at-home RLT

    Five devices spanning portable spot treatment, entry, multi-site, half-body, and full-body use cases. Red light therapy is an emerging adjunct, not a primary keloid treatment.

    Mito Red Light MitoPRO Mobile portable red light therapy device

    Mito Red Light

    Mito Red Light MitoPRO Mobile

    Wavelengths
    630 · 660 · 810 · 830 · 850 nm
    Coverage
    Spot treatment — single keloid site or hard-to-reach areas
    Price
    $340-$400
    BestQool Pro100 red light therapy panel

    BestQool

    BestQool Pro100 Red Light Panel

    Wavelengths
    630 · 660 · 850 · 940 nm
    Coverage
    Upper-body targeted panel — splice up to 4 units for full-body
    Price
    $250-$320
    I ownthis one
    Mito Red Light MitoADAPT MIN 4.0 red light therapy panel

    Mito Red Light

    Mito Red Light MitoADAPT MIN 4.0

    Wavelengths
    590 · 630 · 660 · 670 · 810 · 830 · 850 · 940 nm
    Coverage
    Targeted / medium panel — multiple keloid sites in one session
    Price
    $650-$750
    PlatinumLED BIOMAX 600 half-body red light therapy panel

    PlatinumLED

    PlatinumLED BIOMAX 600

    Wavelengths
    480 · 630 · 660 · 810 · 830 · 850 · 1060 nm
    Coverage
    Half-body — tall narrow panel for torso-length exposure
    Price
    $1000-$1100
    Mito Red Light MitoADAPT MAX 4.0 full-body red light therapy panel

    Mito Red Light

    Mito Red Light MitoADAPT MAX 4.0

    Wavelengths
    590 · 630 · 660 · 670 · 810 · 830 · 850 · 940 nm
    Coverage
    Full-body — single-session exposure for multiple scar sites
    Price
    $1400-$1600

    Affiliate links — I earn a commission if you buy through them. This doesn’t change my evidence rankings. Full disclosure →

Important warnings

Evidence behind this stack

  1. Postoperative Radiotherapy for Keloids: A Meta-Analysis

    2017

    Mankowski P, Kanevsky J, Tomlinson J, et al. · Annals of Plastic Surgery

    Adjuvant radiotherapy after keloid excision reduced recurrence to around 20%, versus over 70% for excision alone.

    View source →
  2. Keloids: A Review of Etiology, Prevention, and Treatment

    2017

    Berman B, Maderal A, Raphael B · Dermatologic Surgery

    Surgical excision combined with adjunctive therapy is more effective than excision alone; recurrence without adjunct can approach 100%.

    View source →

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Medical disclaimer

ScarInsight provides educational information about scar and keloid treatments based on published research. This content is not intended to diagnose, treat, or prevent any medical condition. Individual results vary. Treatment decisions should be made in consultation with a qualified dermatologist or healthcare provider who can evaluate your specific situation. ScarInsight is not a healthcare provider and does not offer medical advice.